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. Please enter a valid email address. View this email in your browser Share. Please reload this tab for.. Loading file data. Editing KWPNMeeting.xml.. Loading file data. Submit. Loading file data. Loading file data. Your message has been sent.[Experiences with isoniazid in the treatment of drug-resistant tuberculosis]. The treatment of drug-resistant tuberculosis (TB) by isoniazid (INH) was initiated at the San Bartolome de Piques TB Centre in January 1994, and several forms of treatment and protocols have been used for the management of this condition. The final objective of the treatment in patients with drug-resistant TB is the eradication of bacilli. Currently, there are several treatment regimens for these cases, all of which use INH for 8-12 months. A retrospective study was conducted of the medical records of 27 patients treated with INH from 1994 to 1997. This regimen was chosen to treat cases of patients classified as highly suspected drug-resistant TB. A 60-day regimen with a high dosage (minimum of 300 mg/day) of INH as well as three of a four-drug regimen was used for 9 months. After a first positive sputum culture, a course of therapy with a regimen of INH, rifampicin (RMP), ethambutol (EMB), and pyrazinamide (PZA) for 2 months was provided. If the subsequent cultures remained positive, therapy with INH, RMP, and PZA for 4 months was recommended. Those patients who failed the treatment after two months of therapy with INH, RMP, EMB and PZA were retreated with the same regimen for four additional months. Treatment with INH, RMP, EMB, PZA, and fluoroquinolones was administered during 8 months of the second phase to patients with EMB-resistance. Twenty-seven patients (18 male and 9 female) were recruited for the study. Two patients died, and one patient was discharged against medical advice. Five patients were lost to follow-up. Twenty-four patients underwent the 6-month phase of treatment; the remaining three patients were discharged before completing 6 months of therapy, because of the absence of positive sputum cultures. In conclusion, INH was effective for the treatment of drug-resistant TB, except in cases of EMB resistance.# http.tcl — # # 37a470d65a


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